Chirumbolo's article (2025) points out that ozone therapy (OOT) does much more than just provide antioxidant protection via glutathione: it activates multiple regulatory pathways in the body that promote repair, regeneration and immune modulation. Glutathione remains important, but only as part of this process, not as a substitute for the broader effectiveness of OOT.
OOT works via multiple pathways (“multi-target intervention”), including redox modulation (regulation of oxidative and reductive processes), endothelial (blood vessel wall) repair, increasing the availability of nitric oxide (NO), and immune reprogramming.
Unlike OOT, intravenous administration of glutathione (IV-GSH) provides only transient antioxidant support without activating upstream adaptive signalling pathways.
Mechanistic modelling (ODE model: ordinary differential equations) was used to estimate the contribution of the GSH/GSSG system to the total effect of OOT. The sensitivity analysis suggested that this contribution is relatively small: less than 10 % in adults and approximately 2 % in the elderly.
The recovery trajectories over six months show that OOT quickly leads to almost complete recovery (in the models), while IV-GSH tends to reach a plateau quickly with minimal improvement.
The authors conclude that OOT is not simply an “antioxidant therapy,” but a systemic bioregulatory treatment — particularly suitable for immune, inflammatory, pain (nociceptive) and degenerative disorders. Glutathione plays a supporting role in this, but cannot replace the multi-pathway action of OOT.
If you would like to know more, please refer to the article on Pub Med: https://pubmed.ncbi.nlm.nih.gov/40991178/
Do you know that nowadays you can arrange many medical matters online whenever and wherever you want? This saves you a telephone contact with our GP practice.
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Do you know that nowadays you can arrange many medical matters online whenever and wherever you want? This saves you a telephone contact with our GP practice.
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Through My Medical Record, it is possible to access your medical record. It is possible to gain insight into the items below:
Do you know that nowadays you can arrange many medical matters online whenever and wherever you want? This saves you a telephone contact with our GP practice.
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For less urgent complaints, you can send us an e-Consult. Our practice then usually answers your query within 48h. Since you don't call, this saves us incoming calls and helps us spread out crowds.
Do you know that nowadays you can arrange many medical matters online whenever and wherever you want? This saves you a telephone contact with our GP practice.
To view and repeat your current medication you need to log in to the patient portal. You will need DigiD for this. Click the button below to log in.
You can use this website to repeat your own chronically active medication. If you take one or more medicines for a longer period, the pharmacy has a free service especially for you: they make sure your medicines are ready at a pre-arranged time.
Do you know that nowadays you can arrange many medical matters online whenever and wherever you want? This saves you a telephone contact with our GP practice. For example, you can view results, request repeat prescriptions or ask your GP a question. You can arrange this in two ways: via the ‘patient environment’ on our website or with the ‘My GP Online’ app.
Your GP puts all the information about your health into a computer. This is called a medical file. For example, the GP puts in what diseases you have, what tests and treatments you have had and what medicines you are taking. This way, your medical information is all together.
Your (GP) doctor and pharmacies can connect their computers to the National Switch Point (LSP). Through the LSP, they can share your most important medical data. Another healthcare provider can view those medical details. The video below briefly explains how the LSP works when you come to the GP surgery.
