{"id":3337,"date":"2025-05-21T15:51:21","date_gmt":"2025-05-21T13:51:21","guid":{"rendered":"https:\/\/heliosneo.nl\/?post_type=praktijkinformatie&p=3337"},"modified":"2025-10-26T12:52:43","modified_gmt":"2025-10-26T11:52:43","slug":"ozon-zuurstoftherapie-o3-o2","status":"publish","type":"praktijkinformatie","link":"https:\/\/heliosneo.nl\/en\/praktijkinformatie\/ozon-zuurstoftherapie-o3-o2\/","title":{"rendered":"Ozone Oxygen Therapy O3-O2"},"content":{"rendered":"
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Ozone Oxygen Therapy O3-O2<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Ozone Oxygen Therapy O3-O2<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Ozone (O\u2083) is a special form of oxygen that plays an important role in both the atmosphere and the medical world. The molecule protects us high in the air against harmful UV radiation, but under certain circumstances it can also have adverse effects on our health, such as in the formation of smog. At the same time, ozone has applications in medicine, where it is used in a controlled form because of its reactive and stimulating properties. Through interaction with the body, ozone can activate processes that promote the production of the body's own antioxidants, which helps to neutralise damage caused by oxidative stress.<\/p><\/div><\/div><\/div>

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But how is ozone-oxygen therapy used here? Is it safe? How does it work?<\/p>

Ozone-oxygen therapy has been known in the medical world for some time. Although ozone in the atmosphere has a protective effect, it can also be harmful to our health, as in the case of smog.<\/p>

Ozone is an unstable molecule that only stabilises when it forms a bond with an oxygen molecule.<\/p>

The O3-O2 gas mixture is highly unstable and reacts immediately with substances in the environment. It is dangerous in high concentrations. In our practice, we use medically approved equipment, the ozone generator from the German company Ozonosan. This produces a precisely measured amount of ozone-oxygen gas, preventing overdoses. This gas mixture is brought into contact with your own blood in a sterile vacuum bottle. A blood thinner is added to prevent clot formation.<\/p>

The first step of the therapy takes place in this 250 ml vacuum bottle. O3 and O2 react with the components of the blood, the protein fats and erythrocytes. This produces so-called (lip)peroxides. These act as biological \u2018messengers\u2019, similar to emails. The blood, enriched with these signalling substances, is returned to the body via a slow infusion.<\/p>

Once inside the body, these peroxides activate the NRF2 protein, which migrates to the cell nucleus (the cell's \u2018town hall\u2019). There, it stimulates the production of the body's own antioxidants via the so-called Antioxidant Response Element (ARE).<\/p>

This leads to the activation of, among others, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR). With these self-activated antioxidants, the body's cells can neutralise damage caused by oxidative stress.<\/p>

There is much more to say about this therapy, how it works and the effects it can have on health.\u00a0<\/p>

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If you have any questions about this therapy, please do not hesitate to contact us.<\/span><\/p>



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SOURCES \u2013 INTERESTING ARTICLES<\/div>\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t
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Chirumbolo S, Franzini M, Ricevuti G, Valdenassi L. Intravenous glutathione should not be mismatched with ozone as an antioxidant therapy. Biomed Pharmacother. 2025 Jul;188:118197. doi: 10.1016\/j.biopha.2025.118197. Epub 22 May 2025. PMID: 40408806.<\/p>

Chirumbolo S, Franzini M, Tirelli U, Valdenassi L. Ozone therapy and the role of the glutathione pathway. Inflammopharmacology. 2025 Oct;33(10):6265-6272. doi: 10.1007\/s10787-025-01953-1. Epub 24 September 2025. PMID: 40991178.<\/p>

de Sire A, Marotta N, Ferrillo M, Agostini F, Sconza C, Lippi L, Respizzi S, Giudice A, Invernizzi M, Ammendolia A. Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review. Int J Mol Sci. 25 February 2022;23(5):2528. doi: 10.3390\/ijms23052528. PMID: 35269681; PMCID: PMC8910188.<\/p>

Jeyaraman M, Jeyaraman N, Ramasubramanian S, Balaji S, Nallakumarasamy A, Patro BP, Migliorini F. Ozone therapy in musculoskeletal medicine: a comprehensive review. Eur J Med Res. 31 July 2024;29(1):398. doi: 10.1186\/s40001-024-01976-4. PMID: 39085932; PMCID: PMC11290204.<\/p>

Pandolfi S, Chirumbolo S, Franzini M, Tirelli U, Valdenassi L. Oxygen-ozone therapy for myocardial ischemic stroke and cardiovascular disorders. Med Gas Res. 1 March 2025;15(1):36\u201343. doi: 10.4103\/mgr.MEDGASRES-D-23-00013. Epub 31 August 2024. PMID: 39217427; PMCID: PMC11515079.<\/p>

Li J, Liu X, Wang Z, Xie P, Zhu M, Zhong H, Luo S, Tang J, Mo G. Ozone therapy mitigates parthanatos after ischaemic stroke. Biol Res. 5 October 2024;57(1):71. doi: 10.1186\/s40659-024-00547-5. PMID: 39367424; PMCID: PMC11453019.<\/p>

Chirumbolo S, Ricevuti G, Franzini M, Vaiano F, Galoforo AC, Richelmi T, Tirelli U, Valdenassi L. Oxygen-ozone adjunct therapy in ageing and senescence-related disorders. State of the art. Adv Pharmacol. 2025;104:417-446. doi: 10.1016\/bs.apha.2025.03.001. Epub 15 April 2025. PMID: 40716938.<\/p>

Viebahn-Haensler R, Le\u00f3n Fern\u00e1ndez OS. Protection of Mitochondria, Cells and Organs from Ischemia-Reperfusion Damage Through Preventive Redox Bioregulation by Ozone. Int J Mol Sci. 10 June 2025;26(12):5557. doi: 10.3390\/ijms26125557. PMID: 40565022; PMCID: PMC12193139.<\/p><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>

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PRACTICAL INFORMATION <\/div>\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t
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Disclaimer: All therapies offered by us are considered complementary to the regularly indicated medical treatment.<\/span><\/p>

Appointments can be cancelled or rescheduled free of charge up to 24 hours in advance. If you cancel within 24 hours or fail to attend the appointment, you will be charged for the cost of the consultation.<\/span><\/p>



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1: Blood sampling.\n<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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2: Filling the OZONOSAM vacuum bottle with your own blood.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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3: Preparation of ozone oxygen gas, with the help of the OZONOSAN alphaplus generator. <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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4: Here, the ozone oxygen gas is brought into contact with the patient's own blood. Lipoperoxides are produced during this process. <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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5: Return of the lipoperoxide-enriched blood. <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Existing literature on ozone.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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